Thursday, July 23, 2015 - 10:30am
Location:P6207a RAND Corporation Building, 4570 Fifth Avenue Suite 600
Speaker:RONGHUI (Lily) XU, Professor of Biostatistics and Bioinformatics http://math.ucsd.edu/people/faculty/Ronghui-Lily-Xu/
Explained variation in survival data has attracted much attention in recent years. In this talk, we consider explained variation in correlated survival data, specifically under the proportional hazards mixed-effects modeling (PHMM) of such data, which provides a natural setting for the decomposition of different sources of variation. A motivation of the concept originated from genetic epidemiology. More generally, explained variation can be formulated in different ways, and we discuss the formulations that are often encountered in the literature and that are interpretable in practice. We study the proposed measures both in theory and through simulation, and discuss some common pitfalls in using and understanding such measures in practice. To conclude, we show some interesting applications to both multi-center clinical trials and recurrent events. — Ronghui (Lily) Xu is Professor of Biostatistics and Bioinformatics at the University of California, San Diego. Her main research areas include survival analysis and random effects models. Dr. Xu received both her Masters in Applied Mathematics (1995) and her Ph.D. (1996) from UCSD. She worked for one year as a graduate researcher at the UCSD Cancer Center and the Department of Mathematics before taking up an Assistant Professorship in 1997 in the Department of Biostatistics, Harvard School of Public Health and the Department of Biostatistical Science, Dana-Farber Cancer Institute in Boston, MA. She returned to UCSD in 2004 as an Associate Professor with the Department of Family and Preventive Medicine and the Department of Mathematics. Visitors to all of RAND’s locations are welcomed to attend and must RSVP one day prior to the seminar. To ensure attendance please, contact nweil [atsymbol] rand.org (Natalia Weil) with your name, company or affiliation & national citizenship (for security purposes).